Comparative Beneficial Effects of Simvastatin and Pravastatin on Cardiac Allograft Rejection and Survival Mandeep R. Mehra, MD, FACC, Patricia A. Uber, PHARMD, Krishnamoorthy Vivekananthan, MD, 1. J Am Coll Cardiol. 2002 Nov 6;40(9):1609-14. Comparative beneficial effects of simvastatin and pravastatin on cardiac allograft rejection and survival. We sought to evaluate the relative effects of low doses of pravastatin (20 mg/day) and simvastatin (10 mg/day) on indices of cardiac allograft rejection. Comparative beneficial effects of simvastatin and pravastatin on cardiac allograft rejection and survival Journal of The American College of Cardiology, 2002 Richard V Milani Atorvastatin, simvastatin, rosuvastatin, and pravastatin have all been shown to have beneficial effects in different clinical settings; however, this is the first comparative study of simvastatin versus another statin in a clinical setting. Comparative beneficial effects of simvastatin and pravastatin on cardiac allograft rejection and survival Article in ACC Current Journal Review 12(2):70 · March 2003 with 24 Reads DOI: 10.1016. Abstract. AbstractObjectivesWe sought to evaluate the relative effects of low doses of pravastatin (20 mg/day) and simvastatin (10 mg/day) on indices of cardiac allograft rejection. Conclusions Simvastatin (10 mg/day) and pravastatin (20 mg/day) are associated with similar beneficial effects on cardiac allograft rejection and one-year survival. At these doses, simvastatin decreases LDL cholesterol more so than pravastatin with no increase in adverse effects in heart transplantation. Lipophilic and hydrophilic statins have different effects on adiponectin and insulin resistance in experimental studies and different effects on the rate of onset of new diabetes in large scale clinical studies. Therefore, we hypothesized that simvastatin and pravastatin may have differential The antibacterial activity of atorvastatin, simvastatin, and rosuvastatin were investigated against 16 standard bacterial strains. Results shown in Table 1 revealed that statins are able to induce variable degrees of antibacterial activity, where atorvastatin and simvastatin are the most potent.